Dual-Tox DPO®: Supporting Phase I & Phase II Detox Pathways (Without the “Detox Hype”)
“Detox” is one of those words that gets thrown around a lot, so I like to keep it grounded and educational. Your body is already built to process and eliminate compounds every day—especially through the liver. When a formula is described as supporting Phase I and Phase II detoxification, it’s referring to the liver’s two-step system for transforming compounds and preparing them for elimination.*
Dual-Tox DPO® is designed to support balanced activity of Phase I and Phase II detoxification processes.* It uses a blend of nutrients and botanical extracts (called Dual Phase Optimizers, or DPO) intended to enhance hepatic detoxification enzyme activity and support healthy detoxification pathways.*
A quick, simple explanation of Phase I vs. Phase II
Phase I is often described as the “activation” step—enzymes transform compounds into intermediate forms.*
Phase II is the “conjugation” step—intermediates are further processed so the body can package them and eliminate them efficiently.*
The goal with a “dual-phase” approach is balance—supporting both phases so the overall process runs smoothly.*
Why does this formula include activated B vitamins and active folate?
Dual-Tox DPO® includes activated forms of:
Vitamin B6 (pyridoxal-5’-phosphate)
Vitamin B12 (methylcobalamin)
It also includes 5-MTHF folate (Quatrefolic®)—described as a biologically active form of folate that supports rapid uptake into the bloodstream.* You may also see 5-MTHF referred to as the “L” form because it is the reduced form of folate.
These nutrients are commonly included in formulas designed to support metabolic and biochemical pathways that depend on B-vitamin cofactor activity.
What stands out about the ingredient strategy
This formula combines:
Botanicals traditionally used for liver and digestive support (like artichoke and milk thistle)
Antioxidant support (like alpha-lipoic acid, green tea extract, and pomegranate hull)
Sulfur-containing and conjugation-support nutrients (like NAC, MSM, and sodium sulfate)
Compounds often used to support healthy clearance pathways (like calcium D-glucarate)
Together, the ingredient list is clearly designed to support enzyme activity and healthy detoxification pathways.*
Ingredients list (Four Capsules Contain)
Vitamin B₆ (as pyridoxal-5’-phosphate) — 50 mg
Folate (as (6S)-5-methyltetrahydrofolic acid, glucosamine salt)† — 680 mcg DFE
Vitamin B₁₂ (as methylcobalamin) — 200 mcg
Artichoke (Cynara scolymus) (aerial parts) extract (5% cynarin) — 600 mg
Watercress (Nasturtium officinale) (whole herb) extract — 500 mg
Milk Thistle (Silybum marianum) (seed) extract (80% silymarin) — 250 mg
alpha-Lipoic Acid — 200 mg
N-Acetyl-L-Cysteine (NAC) — 200 mg
Sodium Sulfate Anhydrous — 200 mg
Green Tea (Camellia sinensis) (leaf) extract (95% polyphenols, 75% catechins, 45% EGCG) — 150 mg
Calcium D-Glucarate — 100 mg
Methylsulfonylmethane (MSM) — 100 mg
Pomegranate (Punica granatum) (hull) extract (40% ellagic acid) — 100 mg
Other Ingredients: Hydroxypropyl methylcellulose (vegetable capsule), microcrystalline cellulose, silicon dioxide.
Does Not Contain: Milk, eggs, fish, shellfish, tree nuts, peanuts, wheat, soy.
Caution + storage
Caution: Keep out of reach of children.
Storage: Keep tightly closed in a cool, dry place.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
