Serrapeptase HP™: What It Is, Why Enteric Coating Matters, and How It Supports Respiratory & Sinus Health

If you’ve ever gone down the “systemic enzyme” rabbit hole, you’ve probably seen serrapeptase come up a lot, especially in conversations around respiratory and sinus support. Today I’m breaking down Serrapeptase HP™, a high-potency serrapeptase supplement designed to support healthy fibrin and promote respiratory and sinus health, with one important feature: it’s enteric-coated.*

First: What is serrapeptase?

Serrapeptase (also called serrapeptidase, serratiopeptidase, or serratia peptidase) is a proteolytic enzyme, meaning it helps break down proteins.

It has a fascinating origin story: serrapeptase is derived from a bacterial species originally found in silkworm intestines. The bacterium Serratia marcescens produces serrapeptase to help the silkworm dissolve its cocoon and emerge as a moth during metamorphosis. Today, serrapeptase is produced through fermentation (Serratia grown in cultures), and the ingredient used here is suitable for vegetarians.

Why Serrapeptase HP™ stands out: the enteric coating

Here’s the issue with many serrapeptase products: they aren’t enteric-coated.

That matters because enzymes like serrapeptase can lose effectiveness when exposed to the highly acidic environment of the stomach. If the enzyme breaks down before it reaches the intestines, you may not get the intended activity.

Serrapeptase HP™ is enteric-coated, which helps it survive stomach acid and reach the intestines, supporting optimal absorption and helping the enzyme remain active.*

In other words: the coating is not just a “nice extra.” It’s a core reason this kind of supplement is formulated the way it is.

What “supports healthy fibrin” means

This product is positioned to support healthy fibrin.* Fibrin is a protein involved in normal clotting and tissue processes. When a supplement mentions fibrin support, it’s usually referring to supporting the body’s normal balance in protein breakdown pathways, which is one reason systemic enzymes are popular in wellness routines.

What it’s commonly used for

According to the product description, Serrapeptase HP™ is intended to support:

• Respiratory health *

• Sinus health *

• Healthy fibrin *

Ingredients list (One capsule contains)

Active ingredient:

• Enteric-Coated Serrapeptase† — 65 mg

  • Serrapeptase — 130,000 SPU

  • MAAC (methacrylic acid copolymer) — enteric coating

Other Ingredients: Hydroxypropyl methylcellulose (vegetable capsule), maltodextrin (from corn), silica.

Does Not Contain: Milk, eggs, fish, shellfish, tree nuts, peanuts, wheat, soy.

Caution + storage

• Caution: If pregnant, nursing, or taking any medications, consult your healthcare practitioner before use. Keep out of reach of children.

• Storage: Keep tightly closed in a cool, dry place.

My HealthMint take

If someone is specifically shopping for serrapeptase, I consider enteric coating a non-negotiable feature. Since enzymes are sensitive and stomach acid is harsh, the coating can make the difference between “looks good on the label” and “actually reaches the place it needs to be.” Serrapeptase HP™ is built with that in mind, and it delivers a clearly stated potency of 130,000 SPU per capsule.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.